Essential NGS Panel

A precise NGS panel, focus on 10 essential genes for clinical target therapy.

EGFR, ALK, ROS1, RET, KRAS, NRAS, PIK3CA, BRAF, HER2, MET

The Essential NGS Panel (Reversible Terminator Sequencing), based on Next Generation Sequencing (NGS) technology, is intended for qualitative detection of SNVs, InDels and Fusions in 10 driver genes in DNA extracted from formalin-fixed paraffin-embedded (FFPE) tissue or plasma sample in patients with NSCLC or CRC by converting sample nucleic acids to sequenceable libraries. The test results are for clinical reference only. The clinician should judge the test results based on the patient’s condition, drug indications, treatment response and other laboratory test indicators comprehensively.

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Product

Number of tests: 24

Name: Essential NGS Panel

Sample type: FFPE tissue or plasma sample

Compatible instruments

  • MiniSeq
  • Miseq
  • Miseq Dx
  • NextSeq Series
  • HiSeq
  • NovaSeq

 

Technological Principles

This kit is developed based on ddCAP technology. Different from normal capture technology, the probes are designed not only for sense strand but also for antisense strand to get better coverage of target region. The Unique Identifier sequences are introduced to both end of each template for tracing back to original template and error correction. With this error correction system, the sensitivity can be down to 0.2%, and applicable for all sample types, including liquid biopsy sample.

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