BRCA 1 and BRCA2 Gene Mutation Detection Kit

The  BRCA1 and BRCA2 Gene Mutation Detection Kit (Reversible Terminator Sequencing), is intended for qualitative detection of BRCA1 and BRCA2 gene mutations (including all coding exons, exon-intron boundaries) in extracted DNA from human blood samples, fresh tissue or neutral formalin-fixed paraffin-embedded (FFPE) tissue samples. The kit is intended to be used to assess BRCA1 and BRCA2 gene status in ovarian cancer and breast cancer patients.

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Number of tests: 24

Name: BRCA 1&2 Gene Mutation Detection Kit

Sample type: Human blood, fresh tissue or FFPE tissue samples

Compatible instruments

  • iSeq 100
  • MiniSeq
  • Miseq
  • Miseq Dx
  • NextSeq Series
  • HiSeq
  • NovaSeq


Technological Principles

The test kit is based on Halo-shape ANnealing and Defer-Ligation Enrichment system (HANDLE system) technology which is an improved Molecular Inversion Probe (MIP) technology to capture the target gene region. The unique molecular identifier (UID) is introduced to both ends of each DNA fragment, and traces back to the original template for error correction. The library construction time of HANDLE system is 5 hours with 1 hour hands-on time.


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